Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly

Li, Y.; Pacoste, L.C.; Gu, W.; Thygesen, S.J.; Stacey, K.J.; Ve, T.; Kobe, B.; Xu, H.; Nanson, J.D.

doi:10.1107/S2059798324008210

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 8
A predicted model of TLR2^TIR-induced MyD88^TIR unidirectional assembly formation. (a) Initially, a TLR2^TIR homodimer (blue) recruits a single MyD88^TIR molecule (magenta). (b) This stepwise assembly involves the addition of successive MyD88^TIR units (2, 3, 4). The subsequent assembly of MyD88^TIR is facilitated by interaction between the EE surface of the incoming monomeric MyD88^TIR and the BB surface of the oligomerized MyD88^TIR subunit, a process that is vital to both the nucleation and elongation stages.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 80| Part 9| September 2024| Pages 699-712

https://doi.org/10.1107/S2059798324008210

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