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![[Figure 9]](gri5001fig9mag.jpg)
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Figure 9
Comparison of MyD88, TLR1, TLR2 and TLR6 TIR-domain structures. (a) Superposition of the MALTIR-induced MyD88TIR structure (PDB entry 7beq; magenta) and TLR2TIR from the crystal structure (PDB entry 1fyw; cyan) and AlphaFold2-predicted oligomer (blue). (b, c) Structural alignment of the crystal structures of TLR2TIR and TLR1TIR (PDB entry 1fyv; green) (b) and TLR6TIR (PDB entry 4om7; yellow) (c). (d, e) Structural alignment of TLR2TIR from our AlphaFold2-predicted oligomer structure and the crystal structures of TLR1TIR (d) and TLR6TIR (e). Conformational differences in the BCD interface, including the αC and αD helices and the CD loop of TLR2TIR (boxed regions), are observed when compared with the crystal structures of TLR1, TLR2 and TLR6 TIR domains. |
![[Figure 9]](gri5001fig9.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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