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Figure 1
Overall fold of Aurora-C and location of the triple SER mutation. (a) Overall complex (chain A) with the INCENP peptide (residues 835–892) in blue and the activation segment (184DFG…PPE209) in green. The three SER mutations, R195A, R196A and K197A, are shown as stick models with the C atoms in magenta. For comparison, (b) shows a structure of Aurora-C (PDB entry 6gr8) with an inhibitor (orange), a longer INCENP peptide (834–903) and without the three SER mutations (residues Arg195, Arg196 and Lys197 shown with C atoms in magenta).

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 80| Part 9| September 2024| Pages 661-674
https://doi.org/10.1107/S2059798324007939
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