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Figure 6
Crystal packing of the KRASG12C–SOS1 complex crystal form. (a) Crystal packing of the complex with KRAS_05 [ribbon representation with KRAS_05 (chain R) in green and SOS1 (chain S) in yellow]. The triple KRAS-to-HRAS mutation D126E/T127S/K128R is shown in magenta (stick representation). Two adjacent symmetry mates are depicted in cyan (SOS1 crystal mate, chain S′) and slate blue (KRAS crystal mate, chain R′). The enlarged view in (b) shows the crystal-contact interactions formed by two residues of the triple KRAS-to-HRAS mutation.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 80| Part 9| September 2024| Pages 661-674
https://doi.org/10.1107/S2059798324007939
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