Figure 2
Methylation. Top: methylation of lysine involves the addition of a methyl group donated by S-adenosylmethionine (SAM) to the side-chain amino group. Bottom: methyllysine (PDB entry 3kmt; Wei & Zhou, 2010; CCD code MLZ). Positive omit density is shown in green at 3σ for the modified residue. The rest of the protein chain is represented by an orange ribbon model. The environment surrounding the modification is shown, indicating that the NZ atom is protonated (hydrogenation of the NZ atom was performed using Coot; Emsley et al., 2010). Hydrogen bonds are displayed as grey dashed lines. |