Figure 3
Hydroxylation. Top: hydroxylation of proline involves the addition of a hydroxyl group donated by 2-oxoglutarate (2OG) to the side-chain pyrrolidine ring. Bottom: hydroxyproline (PDB entry 1gk8; Taylor et al., 2001; CCD code HYP). Positive omit density is shown in green at 3σ for the modified residue. The rest of the protein chain is represented by a purple ribbon model. |