Figure 5
Oxidation. Top: oxidation of cysteine involves the reaction between the side-chain thiol group of cysteine and reactive oxygen species (ROS) to form cysteine sulfenic, then cysteine sulfinic acid and cysteine sulfonic acid (Supplementary Fig. S5). Bottom: cysteine sulfinic acid (PDB entry 1soa; Canet-Avilés et al., 2004; CCD code CSD). Positive omit density is shown in green at 3σ for the modified residue. The rest of the protein chain is represented by a purple ribbon model. |