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![[Figure 4]](ag5052fig4mag.jpg)
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Figure 4
Actin-bound homology models. (a) PDB entry 9d58 (green) and PDB entry 1dxx (violet) aligned with the CH1 domain of utrophin bound to actin (PDB entry 6m5g). The box indicates the region of CH2 that clashes with actin in PDB entry 1dxx. (b) The inset box in (a) showing the position of loops in CH2 that are positioned further from the surface of actin. In the closed CH1–CH2 conformation, actin residue Thr6 clashes with dystrophin residues 157–162. The resolved N-terminal residues of PDB entries 9d58 and 1dxx also clash with actin in this model, indicating that structural changes occur in CH2 upon actin binding. |
![[Figure 4]](ag5052fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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