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![[Figure 1]](gm5113fig1mag.jpg)
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Figure 1
(E)-6-(5-Methoxy-2,6,7-trimethyl-1,3-benzoxazol-4-yl)-4-methylhex-4-enoic acid binds to FABP in a similar manner as a normal fatty acid, with its carboxylic group interacting with Arg127. The hFABP4_5 structure 7fwx is to the left and the hFABP4 structure is to the right. In neither case does the methyl group at the benzoxazole moiety fit the electron density (gray ball-and-stick representation), but the density indicates that the methyl group should be shifted by one atom (blue ball-and-stick representation). Structure 7fvz shows a water molecule in contact with the oxazole, indicating that the heterocycle is not a 1,3-oxazole but a 1,2-oxazole or isoxazole. |
![[Figure 1]](gm5113fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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