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Figure 15
The sulfoxide in 7fxw would not fit next to Arg127. Elimination of DMSO from a racemic mixture leads to an achiral indole-2-carboxylate that recruits a water molecule to bridge the ligand to Arg127. The two conformations of the chlorophenyl group were refined with 70:30 occupancy.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 81| Part 8| August 2025| Pages 451-464
https://doi.org/10.1107/S2059798325006096
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