A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands

Ehler, A.; Bartelmus, C.; Benz, J.; Plitzko, I.; Rudolph, M.G.

doi:10.1107/S2059798325006096

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 23
Unexpected ligands in PDE10. (a) Phosphodiesterase domain of human PDE10 in complex with an aminopyridine ligand. (b) The phenyl substituent of the pyrazole in 5sh8 is at the other N atom compared with the anticipated structure. (c) An aryl imidazole ligand binds at a similar site in 5sks. (d) This ligand has `dimerized' by losing an N-methylacetyl group and forming a biphenyl ether.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 81| Part 8| August 2025| Pages 451-464

https://doi.org/10.1107/S2059798325006096

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