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![[Figure 6]](gm5114fig6mag.jpg)
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Figure 6
Halogen bonds in FABP ligands. The view is identical for all structures. Arg127 and Tyr129 are shown for reference and usually bind to the carboxylate group in the ligand. Note that the ligand in 7fww does not have a carboxylate group: it is neutral but still binds in a similar fashion to the ligands in 7g16 and 7fxa. The first three examples (7g16, 7fxa and 7fww) form a cluster of bromine halogen bonds to the carbonyl group of Ala34. 7fzw displays an unusually short bromine halogen bond, but this structure has also suffered radiation damage, with some of the liberated Br atoms (brown spheres) relocating to van der Waals distance to the Oγ atom of Ser56. This halogen bond should be interpreted with caution. The ligand in 7g18 exhibits two chlorine halogen bonds: one to the carbonyl group of Ala34 and one to the Oγ atom of Ser56. |
![[Figure 6]](gm5114fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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