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![[Figure 7]](gm5115fig7mag.jpg)
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Figure 7
Ligand-dependent change of conformation for the latch residue Phe58 in hFABP4. (a, b) Binding of different fatty acids was shown previously to induce different conformations of Phe58. Linoleic acid (yellow, PDB entry 2q9s) has two cis double bonds at C atoms 9 and 12 that curve the molecule into a U shape. Oleic acid (black, PDB entry 1lid) with a single double bond at C9 reaches out into the solvent. (b) Enlargement of the fatty acids shows that the compact U shape of linoleic acid allows Phe58 to adopt an in-conformation, whereas the extended conformation of oleic acid (black) and the wider U shape of arachidonic acid [brown; shown in (c)] push Phe58 into the out-conformation. (c) Superposition of the ligands in the hFABP4 structures PDB entries 7g1j (green) and 7fzy (magenta) shows Phe58 to adopt intermediate conformations. Ligands in all five cases are in van der Waals contact with Phe58. |
![[Figure 7]](gm5115fig7.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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