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![[Figure 6]](chr5007fig6mag.jpg)
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Figure 6
Binding mode of benzimidazole GSK461364 in the ATP-binding site of PLK1K225D/K226A. (a) Overall view, with PLK1K225D/K226A as a ribbon model and GSK461364 in stick representation (C atoms in green; PDB entry 9r1y). (b) 2Fo − Fc density map contoured at 1.3σ, with Cys133 at the hinge of PLK1 and the gatekeeper residue Leu130 shown in stick representation. Hydrogen bonds are shown as dotted yellow lines. (c, d) View into the ATP-binding site, hinge region on the left; (d) shows a rotated view. PLK1 residues are shown as grey C atoms with a semi-transparent molecular surface. |
![[Figure 6]](chr5007fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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