Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide-bound state

Parker, K.L.; Clarke, J.D.; Liu, X.; Gomes, B.F.; Eyssen, L.E.-A.; Furnham, N.; Paes Silva-Jr, F.; Owens, R.J.

doi:10.1107/S2059798326000422

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 1
Structure of SmCD1. (a) Overall structure of the SmCD1 backbone with the propeptide sequence shown in maroon, disulfide bridges in green and catalytic aspartates shown in stick representation coloured by element. (b) Salt-bridge interactions between Asp84, Asp270 and Lys59.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 82| Part 2| February 2026| Pages 140-150

https://doi.org/10.1107/S2059798326000422

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