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![[Figure 1]](ag5063fig1mag.jpg)
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Figure 1
(a) Two orthogonal views of the TANGO2 structure. (b) Topology diagram of TANGO2. The annotated secondary-structure elements are colored using brown for helices (α1–α6), cyan for β-strands (β1–β14) and gray for coils. (c) The characteristic four-layered αββα fold of TANGO2 and structural superposition between TANGO2 (gray, PDB entry 8sv7) and four known cysteine Ntn-hydrolases, including penicillin acylase (green, PDB entry 2x1d), bile-salt hydrolase (cyan, PDB entry 2hf0), acid ceramidase (brown, PDB entry 5u7z) and N-acylethanolamine-hydrolyzing acid amidase (yellow, PDB entry 6dxx). The structural motifs (α-helices and β-sheets) are labeled to show the consensus αββα fold. |
![[Figure 1]](ag5063fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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