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![[Figure 1]](jb5070fig1mag.jpg)
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Figure 1
Overall architecture and structural comparison of Fsc1. (a) Ribbon diagram of the Fsc1 monomer showing the five tandem FAS1 domains (FAS1-1 to FAS1-5), colored sequentially from the N-terminus to the C-terminus. (b) Domain organization of Fsc1, highlighting the continuous fasciclin repeat architecture without intervening motifs, and showing the short single-pass transmembrane and vacuolar domain in yellow (predicted by AlphaFold); the coloring scheme is consistent with that in (a). (c) Superposition of crystal forms A (cyan) and B (gray), showing structural consistency with minor variations. R.m.s.d. = 0.649 Å. (d) Global comparison of the AlphaFold-predicted Fsc1 structure (in warm pink) to experimental structures of forms A (cyan, r.m.s.d. = 6.192 Å) and B (gray, r.m.s.d. = 4.178 Å). (e) Pairwise structural comparison of individual FAS1 domains between AlphaFold-predicted Fsc1 and both crystal forms; the coloring scheme is consistent with (d). |
![[Figure 1]](jb5070fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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