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![[Figure 4]](jb5070fig4mag.jpg)
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Figure 4
Sequence conservation and comparative surface topography of FAS1 domains. (a) Multiple sequence alignment of Fsc1 and human fasciclin proteins TGFBI and periostin, highlighting the conserved H1, YH and H2 motifs. (b) Comparative surface analysis of human homologs. Surface representations of TGFBI (lemon; PDB entry 5nv6) and periostin (wheat; PDB entry 5yjg) are shown, with regions corresponding to the Fsc1 FAS1-4 groove highlighted in red, demonstrating conserved surface topology across species as corroborated by the sequence alignment. (c) ConSurf analysis and conservation mapping of Fsc1, with the molecular surface colored according to evolutionary conservation score. Key features, including the H1 and H2 motifs and the FAS1-4 groove, are labeled to highlight their localization within highly conserved regions. |
![[Figure 4]](jb5070fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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