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![[Figure 1]](id5015fig1mag.jpg)
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Figure 1
Contextualization of lipid densities and applications of SURFER. (a) Raw and contextualized cryo-EM density maps for γ-secretase in amphipol A8-35 (EMDB entry EMD-3061), COPII coat on lipid bilayers (EMDB entry EMD-15949) and the mechanosensitive channel TMEM63A in lipid nanodiscs (EMDB entry EMD-28153). (b) Schematic illustration of SURFER segmentation and subtraction of lipid micelle for visualization with LocScale-2.0-optimized maps or for particle subtraction for 3D refinement. The example shown is the pentameric calcium-sensitive channel DeCLIC from Desulfofustis glycolicus reconstituted in lipid nanodiscs (EMDB entry EMD-19995). The LocScale-FEM pVDDT confidence score is mapped onto the optimized map. |
![[Figure 1]](id5015fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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