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![[Figure 2]](id5015fig2mag.jpg)
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Figure 2
Training dataset generation for membrane/detergent segmentation. (a) Difference mask generation for isolation of lipid density regions illustrated with α1β3γ2L GABAA receptor in lipid nanodiscs (EMDB entry EMD-0275). Left: raw average of the unfiltered half maps from which the FDR confidence mask is generated. The ordered volume is estimated from the deposited atomic model (PDB entry 6hug) and subtracted from the FDR-enclosed volume to generate a difference mask. Note that the raw difference mask is not restricted to the detergent micelle but can encompass other unmodelled signal. (b) Predicted membrane planes relative to the atomic model and the raw difference mask and procedure of edge detection to refine plane positioning at the detergent boundary. The segmented detergent micelle volume is shown on the far right. |
![[Figure 2]](id5015fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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