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![[Figure 4]](jc5068fig4mag.jpg)
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Figure 4
Ligand-binding structures of GH30 enzymes. (a) Surface representation of the covalent complex of HsGCase with cyclohexitol (PDB entry 1y7v, GH30_1). The bound conduritol derivative is shown as a cyan ball-and-stick model. (b) Surface representation of the MeGX3-binding structure of DcXynA (PDB entry 2y24, GH30_8). The bound MeGX3 and imidazole molecules are shown as ball-and-stick models in orange and brown, respectively. (c) Surface representation of the MeGX2-binding structure of BsXynC (PDB entry 3kl5, GH30_8; St John et al., 2011  ). The bound MeGX2 molecule is shown as a ball-and-stick model in magenta. (d) Surface representation of the Gal2-binding structure of Sa16Gal30A. The bound Gal2 and MES molecules are shown as ball-and-stick models with gray and green C atoms, respectively, and protein residues are shown as stick models colored in a rainbow representation. (e) Superposition of ligand-binding structures around the catalytic cleft of the Sa16Gal30A–Gal2 (black), HsGCase–cyclohexitol (cyan), DcXynA–MeGX3 (orange) and BsXynC–MeGX2 (magenta) complexes. (f) Superposition of the bound sugar molecules shown in (e). Catalytic residues and the bound MES (dark green) and imidazole (brown) molecules in the Sa16Gal30A–Gal2 and DcXynA−MeGX3 complexes are shown. |
![[Figure 4]](jc5068fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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