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Figure 5
Comparison of the donor sites in human ARTD complex structures containing NAD+ analogues. (a) Poly-ARTDs PARP1 and TNKS2. Notable structural differences include the conformations of the D-loop, the narrower adenosine subsite restricted by the F-loop in TNKS2, and the longer G-loop in TNKS2. (b) Mono-ARTDs PARP15 and PARP16. The donor sites are shaped similarly to each other as well as to PARP1, except for the different conformations of the D-loop.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 82| Part 8| August 2026| Pages 998-1008
https://doi.org/10.1107/S2059798326006868
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