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![[Figure 6]](rr5265fig6mag.jpg)
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Figure 6
The D-loop (coloured range Glu1046–Gly1058 at the top of each panel) is observed in three distinct conformations in the TNKS2CAT complex structures. The adenosine and nicotinamide subsites of the NAD+-binding donor site are labelled ADE and NI, respectively. (a) In TNKS2CAT+BAD the D-loop is completely open as in PDB entry pdb_00007ojo (TNKS2CAT+2+3). (b) In TNKS2CAT+4 and TNKS2CAT+6 the D-loop covers the nicotinamide subsite in a way that would clash with BAD. (c) In TNKS2CAT+5 the D-loop is partially closed as in PDB entry pdb_00008b6m (TNKS2CAT+4), and this conformation most resembles the closed conformation in the apo form (PDB entry pdb_00003kr7). |
![[Figure 6]](rr5265fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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