Structural basis for a p21-activated kinase 4 and nicotinamide phosphoribosyltransferase dual inhibitor

Park, J.; Hong, H.R.; Han, S.H.; Song, J.; Son, S.-Y.; Choi, S.; Park, S.M.; Lee, W.-K.; Jiko, C.; Kim, J.-H.; Jee, J.-G.; Bang, J.K.; Park, I.Y.; Lee, S.J.

doi:10.1107/S2059798326006145

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 1
Chemical structures of (a) KPT-9274 and (b) KPT-7523. The 2-aminopyridine moieties, which are critical for dual inhibition of PAK4 and NAMPT, are highlighted in red.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 82| Part 8| August 2026|

https://doi.org/10.1107/S2059798326006145

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