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![[Figure 4]](wa5155fig4mag.jpg)
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Figure 4
Co-crystal structure of the NAMPT dimer with KPT-7523. (a) The crystal structure of the NAMPT dimer with KPT-7523 is depicted as a cartoon with the NAMPT monomers shown in light blue (A chain) and light pink (B chain) and KPT-7523 in yellow ball-and-stick representation. (b) Details of KPT-7523 (yellow) binding (a fragment with unclear electron density is depicted in gray). Important hydrogen bonds are depicted as deep purple dashed lines. (c) Structural overlay of KPT-7523 (yellow) and KPT-9274 (cyan) bound to NAMPT (PDB entry 5nsd), highlighting their distinct binding conformations. |
![[Figure 4]](wa5155fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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