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![[Figure 6]](xh5065fig6mag.jpg)
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Figure 6
Dose-dependent trends in (a) occupancies, (b) distances and (d) angles for chain A (purple) and chain B (green). Statistical significance of individual trends is marked with asterisks (*, p < 0.05; **, p < 0.01; ***, p < 0.0001) and statistically significant contrasts between chains are highlighted with a light blue bar. (c) Schematic of the angles measured. θ1, θ2 and θ3 represent the angle formed between the copper and two of its nitrogen ligands. θH–H is the acute angle between the imidazole ring planes of His1 and His84. θT is the angle between the Cu–Nterm–His1 Nδ plane and the Cu–His84 Nɛ line. θH1 and θHN denote angles between an imidazole ring plane and a line extending from the copper to the copper-coordinating atom in the same histidine. For NcAA9D, θH1 corresponds to His1 and θHN to His84. The measurement of θHN is illustrated above. For this study, the imidazole ring planes were defined by the coordinates of their Nδ, Nɛ and Cγ atoms. |
![[Figure 6]](xh5065fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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