Structure and allostery in major facilitator superfamily symport mechanisms

Guan, L.

doi:10.1107/S2059798326007485

Figure 7
Schematic illustration of uniport, symport and antiport processes of MFS transporters. (a) Uniport mechanism in the D59C MelB_St mutant. (b) Na⁺/melibiose symport mechanism. The stepped-binding models are described in the main text. MelB_St, Na⁺ and melibiose are labeled. The steps [1–4] in the uniport mode and [2–5] in the symport mode are involved in the melibiose-exchange reaction and highlighted in blue or green on the arrows, respectively. This figure was modified from Fig. 6 of Guan & Hariharan (2021

). (c) H⁺/xenobiotics antiport mechanism. Xenobiotics and H⁺ are labeled. This anticooperativity-based `ping-pong' exchange mechanism is described in the main text.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 82| Part 9| September 2026| Pages 1030-1043

https://doi.org/10.1107/S2059798326007485

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