KAT6A–inhibitor co-crystal structures: tackling a challenging crystallization target via two alternative approaches

Puetter, V.; Bouché, L.; Nowak-Reppel, K.; Ferrara, S.J.; Gradl, S.N.; Korr, D.; Strathdee, C.A.; ter Laak, A.; Hillig, R.C.

doi:10.1107/S2059798326008545

Figure 2
Crystals of KAT6A^mutCys and of KAT8^mutant/MYST^cryst. (a) shows typical plate-shaped crystals of KAT6A^mutCys in complex with AcCoA obtained after one round of streak-seeding. (b) shows a representative KAT8^mutant/MYST^cryst–inhibitor co-crystal obtained in a streak-seeded fine-screen, here with the lead compound BAY-7728 (ter Laak et al., 2026

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 82| Part 9| September 2026| Pages 1111-1124

https://doi.org/10.1107/S2059798326008545

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