KAT6A–inhibitor co-crystal structures: tackling a challenging crystallization target via two alternative approaches

Puetter, V.; Bouché, L.; Nowak-Reppel, K.; Ferrara, S.J.; Gradl, S.N.; Korr, D.; Strathdee, C.A.; ter Laak, A.; Hillig, R.C.

doi:10.1107/S2059798326008545

Figure 4
Co-crystal structure of KAT6A^mutCys in complex with WM-8014. (a) shows the tool compound WM-8014 (stick representation, C atoms in yellow) bound within the AcCoA-binding site of KAT6A (PDB entry 29ur, chain B). Residues lining the inhibitor-binding site are drawn in stick representation. The final 2F_o − F_c electron-density map contoured at 1.0σ is shown in blue. (b) shows the same view, now superimposed with the co-crystal structure of the co-complex of the same inhibitor in complex bound to KAT8^mutant/MYST^cryst (PDB entry 6ba2; Baell et al., 2018

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 82| Part 9| September 2026| Pages 1111-1124

https://doi.org/10.1107/S2059798326008545

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