KAT6A–inhibitor co-crystal structures: tackling a challenging crystallization target via two alternative approaches

Puetter, V.; Bouché, L.; Nowak-Reppel, K.; Ferrara, S.J.; Gradl, S.N.; Korr, D.; Strathdee, C.A.; ter Laak, A.; Hillig, R.C.

doi:10.1107/S2059798326008545

Figure 6
Crystal structure of KAT8^mutant/MYST^cryst in complex with Example 41. (a) The inhibitor Example 41 (Morrow et al., 2018

; later termed compound 29n; Suwandi et al., 2026

) is depicted in stick representation with C atoms in cyan (PDB entry 29uu). The final 2F_o − F_c electron-density map (1.3 Å resolution, contoured at 1.3σ) is shown in blue. Hydrogen bonds are depicted as yellow dotted lines. (b) Superimposition of the previously published crystal structure of KAT8^mutant/MYST^cryst in complex with inhibitor WM-8014 (PDB entry 6ba2; Baell et al., 2018

), depicted in stick representation with C atoms in yellow.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 82| Part 9| September 2026| Pages 1111-1124

https://doi.org/10.1107/S2059798326008545

Open

access