Fragment-based active-site exploration of urethane hydrolases reveals a diversity of urethane binding modes

Bicer, D.; Kochubei, D.; Graham, R.; Peña-Díaz, S.; Rotilio, L.; Villadsen, N.L.; Sommerfeldt, A.; Johansen, M.B.; Sandahl, A.; Thirup, S.S.; Morth, J.P.; Otzen, D.E.

doi:10.1107/S2059798326010624

Figure 1
Structures of PU fragments. Substrates: (a) DUE-MDA and (b) DUE-2,4-TDA. Single urethane bond-degraded intermediate products: (c) MUE-MDA, (d) MUE-2,4-TDA, (e) DUE-2,6-TDA, (f) DUP-2,6-TDA. Double urethane bond-cleaved products: (g) 4,4-MDA, (h) 2,4-TDA. DUE, diurethane ethylene glycol; MUE, monourethane ethylene glycol; DUP, diurethane polypropylene glycol; MDA; methylene dianiline; TDA, toluenediamine. This figure was made with ChemAxon.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 82| Part 11| November 2026| Pages 1298-1317

https://doi.org/10.1107/S2059798326010624

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