most read articles
These are the most read articles in the last six months.
A snapshot love story: what serial crystallography has done and will do for us. (2024). Acta Cryst. D80, 563-579.
Factors affecting macromolecule orientations in thin films formed in cryo-EM. (2024). Acta Cryst. D80, 535-550.
The CCP4 suite: integrative software for macromolecular crystallography. (2023). Acta Cryst. D79, 449-461.
Cryo2RT: a high-throughput method for room-temperature macromolecular crystallography from cryo-cooled crystals. (2024). Acta Cryst. D80, 620-628.
A structural role for tryptophan in proteins, and the ubiquitous Trp Cδ1—HO=C (backbone) hydrogen bond. (2024). Acta Cryst. D80, 551-562.
High-confidence placement of low-occupancy fragments into electron density using the anomalous signal of sulfur and halogen atoms. (2024). Acta Cryst. D80, 451-463.
Introduction of the Capsules environment to support further growth of the SBGrid structural biology software collection. (2024). Acta Cryst. D80, 439-450.
Likelihood-based interactive local docking into cryo-EM maps in ChimeraX. (2024). Acta Cryst. D80, 588-598.
Utilizing anomalous signals for element identification in macromolecular crystallography. (2024). Acta Cryst. D80, 713-721.
Tomo Live: an on-the-fly reconstruction pipeline to judge data quality for cryo-electron tomography workflows. (2024). Acta Cryst. D80, 247-258.
Validation of electron-microscopy maps using solution small-angle X-ray scattering. (2024). Acta Cryst. D80, 493-505.
Pillar data-acquisition strategies for cryo-electron tomography of beam-sensitive biological samples. (2024). Acta Cryst. D80, 421-438.
The success rate of processed predicted models in molecular replacement: implications for experimental phasing in the AlphaFold era. (2024). Acta Cryst. D80, 766-779.
STOPGAP: an open-source package for template matching, subtomogram alignment and classification. (2024). Acta Cryst. D80, 336-349.
The crystal structure of Shethna protein II (FeSII) from Azotobacter vinelandii suggests a domain swap. (2024). Acta Cryst. D80, 599-604.
Managing macromolecular crystallographic data with a laboratory information management system. (2024). Acta Cryst. D80, 580-587.
From femtoseconds to minutes: time-resolved macromolecular crystallography at XFELs and synchrotrons. (2024). Acta Cryst. D80, 60-79.
EMinsight: a tool to capture cryoEM microscope configuration and experimental outcomes for analysis and deposition. (2024). Acta Cryst. D80, 259-269.
What shapes template-matching performance in cryogenic electron tomography in situ?. (2024). Acta Cryst. D80, 410-420.
Surface-mutagenesis strategies to enable structural biology crystallization platforms. (2024). Acta Cryst. D80, 661-674.
FLEXR: automated multi-conformer model building using electron-density map sampling. (2023). Acta Cryst. D79, 354-367.
Deep-learning map segmentation for protein X-ray crystallographic structure determination. (2024). Acta Cryst. D80, 528-534.
Likelihood-based signal and noise analysis for docking of models into cryo-EM maps. (2023). Acta Cryst. D79, 271-280.
CHiMP: deep-learning tools trained on protein crystallization micrographs to enable automation of experiments. (2024). Acta Cryst. D80, 744-764.
EMhub: a web platform for data management and on-the-fly processing in scientific facilities. (2024). Acta Cryst. D80, 780-790.
Protein–macrocycle polymorphism: crystal form IV of the Ralstonia solanacearum lectin–sulfonato-calix[8]arene complex. (2023). Acta Cryst. D79, 624-631.
Comparison of two crystal polymorphs of NowGFP reveals a new conformational state trapped by crystal packing. (2024). Acta Cryst. D80, 686-698.
Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket. (2024). Acta Cryst. D80, 123-136.
The TR-icOS setup at the ESRF: time-resolved microsecond UV–Vis absorption spectroscopy on protein crystals. (2024). Acta Cryst. D80, 16-25.
Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy. (2023). Acta Cryst. D79, 111-121.
Protein model refinement for cryo-EM maps using AlphaFold2 and the DAQ score. (2023). Acta Cryst. D79, 10-21.
Investigation of how gate residues in the main channel affect the catalytic activity of Scytalidium thermophilum catalase. (2024). Acta Cryst. D80, 101-112.
Right-handed Z-DNA at ultrahigh resolution: a tale of two hands and the power of the crystallographic method. (2023). Acta Cryst. D79, 133-139.
Accelerating crystal structure determination with iterative AlphaFold prediction. (2023). Acta Cryst. D79, 234-244.
Analysis of crystallographic phase retrieval using iterative projection algorithms. (2024). Acta Cryst. D80, 800-818.
Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris. (2023). Acta Cryst. D79, 735-745.
Structural insight into an anti-BRIL Fab as a G-protein-coupled receptor crystallization chaperone. (2023). Acta Cryst. D79, 435-441.
A database overview of metal-coordination distances in metalloproteins. (2024). Acta Cryst. D80, 362-376.
Structural analysis of a ligand-triggered intermolecular disulfide switch in a major latex protein from opium poppy. (2024). Acta Cryst. D80, 675-685.
Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly. (2024). Acta Cryst. D80, 699-712.
Structure and stability of an apo thermophilic esterase that hydrolyzes polyhydroxybutyrate. (2024). Acta Cryst. D80, 791-799.
Structural studies of β-glucosidase from the thermophilic bacterium Caldicellulosiruptor saccharolyticus. (2024). Acta Cryst. D80, 733-743.
Neutron crystallographic refinement with REFMAC5 from the CCP4 suite. (2023). Acta Cryst. D79, 1056-1070.
A user-friendly plug-and-play cyclic olefin copolymer-based microfluidic chip for room-temperature, fixed-target serial crystallography. (2023). Acta Cryst. D79, 944-952.
LifeSoaks: a tool for analyzing solvent channels in protein crystals and obstacles for soaking experiments. (2023). Acta Cryst. D79, 837-856.
Deep residual networks for crystallography trained on synthetic data. (2024). Acta Cryst. D80, 26-43.
Using cryo-EM to understand the assembly pathway of respiratory complex I. (2024). Acta Cryst. D80, 159-173.
Raynals, an online tool for the analysis of dynamic light scattering. (2023). Acta Cryst. D79, 673-683.
AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography. (2024). Acta Cryst. D80, 270-278.
Identifying and avoiding radiation damage in macromolecular crystallography. (2024). Acta Cryst. D80, 314-327.
20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening. (2023). Acta Cryst. D79, 198-205.
Molecular-dynamics simulation methods for macromolecular crystallography. (2023). Acta Cryst. D79, 50-65.
HEIDI: an experiment-management platform enabling high-throughput fragment and compound screening. (2024). Acta Cryst. D80, 328-335.
Efficient in situ screening of and data collection from microcrystals in crystallization plates. (2024). Acta Cryst. D80, 279-288.
Structural analysis of wild-type and Val120Thr mutant Candida boidinii formate dehydrogenase by X-ray crystallography. (2023). Acta Cryst. D79, 1010-1017.
Structural basis of regioselective tryptophan dibromination by the single-component flavin-dependent halogenase AetF. (2023). Acta Cryst. D79, 596-609.
Structural and functional characterization of a multi-domain GH92 α-1,2-mannosidase from Neobacillus novalis. (2023). Acta Cryst. D79, 387-400.
Announcing the launch of Protein Data Bank China as an Associate Member of the Worldwide Protein Data Bank Partnership. (2023). Acta Cryst. D79, 792-795.
Multivariate estimation of substructure amplitudes for a single-wavelength anomalous diffraction experiment. (2023). Acta Cryst. D79, 339-344.
A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA. (2024). Acta Cryst. D80, 350-361.
Analysis and validation of overall N-glycan conformation in Privateer. (2023). Acta Cryst. D79, 462-472.
Module walking using an SH3-like cell-wall-binding domain leads to a new GH184 family of muramidases. (2023). Acta Cryst. D79, 706-720.
Overall protein structure quality assessment using hydrogen-bonding parameters. (2023). Acta Cryst. D79, 684-693.
2023 update of template tables for reporting biomolecular structural modelling of small-angle scattering data. (2023). Acta Cryst. D79, 122-132.
Crystal-packing analysis of translation initiation factor 2 reveals new details of its function. (2024). Acta Cryst. D80, 464-473.
Structural and functional characterization of the novel endo-α(1,4)-fucoidanase Mef1 from the marine bacterium Muricauda eckloniae. (2023). Acta Cryst. D79, 1026-1043.
Advanced exploitation of unmerged reflection data during processing and refinement with autoPROC and BUSTER. (2024). Acta Cryst. D80, 148-158.
A service-based approach to cryoEM facility processing pipelines at eBIC. (2024). Acta Cryst. D80, 174-180.
Cryo-EM structure of adeno-associated virus 4 at 2.2 Å resolution. (2023). Acta Cryst. D79, 140-153.
Correcting systematic errors in diffraction data with modern scaling algorithms. (2023). Acta Cryst. D79, 796-805.
Elucidating polymorphs of crystal structures by intensity-based hierarchical clustering analysis of multiple diffraction data sets. (2023). Acta Cryst. D79, 909-924.