N-(1,3-Thiazol-2-yl)-2-(2,4,6-trimethylphenyl)acetamide

In the title compound, C14H16N2OS, the thiazole ring is essentially planar (r.m.s. deviation = 0.005 Å) and it forms a dihedral angle of 75.21 (8)° with the benzene ring. In the crystal, molecules are linked into inversion dimers by pairs of N—H⋯N hydrogen bonds to generate R 2 2(8) loops.

In the title compound, C 14 H 16 N 2 OS, the thiazole ring is essentially planar (r.m.s. deviation = 0.005 Å ) and it forms a dihedral angle of 75.21 (8) with the benzene ring. In the crystal, molecules are linked into inversion dimers by pairs of N-HÁ Á ÁN hydrogen bonds to generate R 2 2 (8) loops.

Comment
In continuation of our work on synthesis of amides (Fun et al., 2011a(Fun et al., ,b, 2012, we report herein the crystal structure of the title compound.
Colourless blocks were grown from an acetone and toluene (1:1) solvent mixture by the slow evaporation method (m.p.

Refinement
N-bound hydrogen atom was located in a difference Fourier map and refined using a riding model with U iso (H) = 1.2 U eq (N) [N-H = 0.8794 Å]. The remaining H atoms were positioned geometrically and refined using a riding model with C-H = 0.95-0.99 Å and U iso (H) = 1.2 or 1.5U eq (C). A rotating-group model was applied for the methyl groups.   The crystal structure of the title compound, viewed along the b axis. H atoms not involved in hydrogen bonds (dashed lines) have been omitted for clarity.

N-(1,3-Thiazol-2-yl)-2-(2,4,6-trimethylphenyl)acetamide
Crystal data  (Cosier & Glazer, 1986) operating at 100.0 (1) K. Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. Refinement. Refinement of F 2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F 2 , conventional R-factors R are based on F, with F set to zero for negative F 2 . The threshold expression of F 2 > 2sigma(F 2 ) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F 2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger.