When a dream comes true: birth of the African Crystallographic Association (AfCA)

This paper summarizes brief perspectives on the historic process of establishing an African Crystallographic Association (AfCA), including appropriate role players, organizations and accompanying events. It concludes with the official admission of AfCA as the fifth Regional Associate of the IUCr at the 26th Congress and General Assembly of the IUCr in Melbourne, Australia in 2023.


Introduction
This paper summarizes brief perspectives on the historic process of establishing an African Crystallographic Association (AfCA), and includes selected, but hopefully representative references.However, it never claims to give detailed early referencing, primarily since these are not readily available, and moreover, it would be too extensive.The paper covers four arbitrarily selected time slots and ends with the official admission of AfCA as the fifth Regional Associate of the IUCr at the 26th Congress and General Assembly of the IUCr in Melbourne, Australia.
In the author's view, crystallography 'arrived' in Africa at different times but in two fairly distinct thrusts, namely, in (i) South Africa, being a British colony and therefore having direct contact with the Bragg group, and (ii) North Africa via the principally French/Arabic regions.The latter proceeded somewhat slower than the former.
These are briefly summarized in Section 2 and are considered important to illustrate crystallographic activity in countries across Africa.Up to now, Africa was incorporated under the European Crystallographic Association (ECA), since until 1999 crystallography was only practiced significantly in five African countries, i.e., South Africa, Egypt, Tunisia, Algeria, and Morocco.Moreover, by 1999 only Egypt (1978) and South Africa (1950) were members of the IUCr, while Algeria, Cameroon and Morocco joined in 2014 (Haynes, 2023;IUCr, 2014a), and Tunisia in 2017 (IUCr, 2017).
Table 1 lists the selected time slots wherein the development of crystallographic activity in Africa are arbitrarily grouped, i.e. (i) up to 1999, (ii) 2000-2013, (iii) 2014-2019, and (iv) 2020 onwards.Also indicated therein are some individuals and associations closely related with activities and outcomes.More details on these time slots are discussed stepwise in Sections 3-6.

South Africa
Mineralogical/Geological activity was, as expected, at the forefront earlier due to the never-ending quest for valuable minerals and gemstones.To this effect Geology in South Africa (SA) was already organized in the 1890s (GSSA, 1896), with the first talk presented by Draper (1896).Mineralogy was formally organized only some five decades later.
The appointment of Alexander Ogg as professor in Physics in 1905 at the Rhodes University College, Grahamstown (now Makhanda), SA, saw crystallography formally take off (Plug, 2020).Ogg then moved to the South African School of Mines and Technology (soon to become the University of the Witwatersrand) in Johannesburg from 1917 to 1919, and then to the University of Cape Town (UCT) from 1920 to 1936 (Plug, 2020;Schonland, 1948).He collaborated with W. H. Bragg (who often presented Ogg's research at the Royal Society) and during this period published probably some of the earliest crystallography in South Africa (Ogg & Hopwood, 1916;Ogg, 1922Ogg, , 1928)).R. W. James was Ogg's successor at UCT (James, 1948a;James & Saunder, 1948) and collaborated with W. L. Bragg (Bragg et al., 1922), and also produced a wellknown textbook for the time (James, 1948b).In the late 1940s, mainly under the influence of James, a school of X-ray analysis was started at UCT, which focused amongst others on the structure of aromatic molecules and molecular compounds using three-dimensional methods, extending the analyses to cover cases of molecular disorder (Bernal, 1962) , 1982), who did his first X-ray work in Cape Town (James, 1962).It was here at UCT that Klug began his studies on the use of Fourier transforms in crystal analysis, essential to his work on viruses.

North/West Africa
Representative work in different fields of crystallography were produced in the latter decades of the 20th century by different researchers in Egypt, Tunisia, Algeria, and Morocco, following involvement of French universities at Bordeaux, Grenoble, Lille, Nancy, Paris, and Poitiers (Lecomte, 2021).Dorothy Hodgkin (Nobel Prize for Chemistry, 1964) was African born (Egypt) and contributed to the expansion of crystallography in North/West Africa.She was an honorary professor at the University of Ghana (1961Ghana ( -1962)), and an honorary fellow of the Ghana Academy of Sciences (1965), and delivered a number of lectures during this period (Bodleian Libraries, 1993).Unfortunately, the coup in Ghana in 1966 severely delayed the further establishment of crystallography in Ghana.

Jan Boeyens and the IUCr in the 1990s
The IUCr Crystallography in Africa initiative was launched in 1999 following a proposal of former IUCr Executive Committee member Jan Boeyens from South Africa, with the aim of developing programmes and activities for the dissemination of crystallography on the African continent.
Part of this early initiative was the transfer of old (but still working) instruments into Africa, e.g., to Nairobi, Kenya.The first was a single-crystal diffractometer donated by the CCDC while a second was a powder diffractometer from Boeyens' lab (Levendis, 2007).
Prior to this, the establishment of the Indaba series in South Africa in 1995 by Boeyens created an additional portal for building out South African, and indeed African crystallography (Liles, 2015).These were supported by the IUCr Small Molecules Commission.
At the 17th IUCr Congress and General Assembly in Seattle in 1996, South Africa under the leadership of Jan Boeyens, Luigi Nassimbeni and Gert Kruger, launched an initiative to host the 19th IUCr Congress and General Assembly in 2002.South Africa lost the vote to Israel, and disappointingly this meeting was later moved to Geneva in Switzerland.The successful hosting of ECM21 paved the way for ECM24 to follow in Morocco; thus, two ECMs were hosted on the African continent is a short space of four years.Both these meetings ensured significant expanded interaction across Africa.
Additional impetus for expanding North African crystallography is reflected in the first North African Conference in Morocco in November 2010, especially as it was attended by senior representatives of IUCr, ACA, AsCA and ECA (Kelly, 2011), as evidence of growing momentum towards developing crystallography in North Africa.
In addition, very importantly, during the period 2010-2013, a synchronized initiative to declare an International Year of Crystallography was launched.A. Thalal from Morocco, strongly supported by the IUCr (S.Larsen, President, IUCr, 2008-2011;andC. Lecomte, Vice President, IUCr, 2011-2014) and UNESCO (M.Nalecz and J. J.-P.Ngome Abiaga from the International Basic Sciences Programme), took the significant initiative to apply to the United Nations (IUCr, 2014ab,c).A concise timeframe for finally establishing an international year for crystallography was as follows (Thalal & Zema, personal communication): •December 2010: start of the process for submitting the proposal for IYCr2013 through UNESCO.
•March 2011: after the Permanent Delegation of Morocco to UNESCO gave positive feedback, the process stops because time was too short.
•April 2011: start of the process again by submitting the proposal directly to the UN.Draft resolution is prepared and political action undertaken.
•November 2011: it is suggested to propose 2014 as IYCr (at this time, G. Desiraju is President and C. Lecomte Vice President of the IUCr).
•March 2012: draft resolution is submitted to the UN.The Moroccan Delegation succeeds in convincing six countries (Australia, Belgium, Luxembourg, Mexico, Poland and the Dominican Republic) to cosign the draft resolution and obtains unanimous support from the other delegations.
The successful declaration of IYCr2014 by the UN resulted in significant energy being injected into crystallography on a world-wide scale, and particularly in Africa.In 2013, M. Zema was appointed by the IUCr as Project Manager for the International Year of Crystallography (IYCr2014), becoming Outreach Officer in February 2015, and eventually Executive Outreach Officer in October 2015.Confirmation of the success of the International Year of Crystallography is manifested by much literature all around the world (IUCr, 2014b).
As part of this initiative, A. Roodt was approached in 2013 by the then IUCr President, Gautam Desiraju, to host one of the three world summits in Africa, and proceeded with organizing IYCr2014 Africa under the title 'Crystallography as a vehicle to promote science in Africa and beyond'.Significant initiatives in Africa flowed from this, as indicated in Section 4.

Period 2014-2019
Supported by the South African Government, UNESCO and the IUCr, IYCr2014 Africa, the Pan-African Conference and Summit was hosted in Bloemfontein, South Africa, towards the end of 2014 (Roodt & Zema, 2014;IYCr2014 Africa;Fig. 2).Delegates from more than twenty countries attended and discussions to expand initiatives on establishing AfCA commenced with more urgency.
Among the important initiatives flowing from IYCr2014 Africa was one to urge associated decision makers to (i) proactively continue programmes, ensuring the legacy of IYCr2014 and promotion of science was preserved and expanded, and (ii) over time provide basic diffraction equipment (but also other scientific infrastructure) for researchers in African countries to allow broader research in crystallography, see resolutions (Roodt & Zema, 2014).
Moreover, the organisers committed to push forward with AfCA.Hence, IYCr2014 Africa enabled a focused action to establish an African Crystallographic Association, with many African research groups being represented.It was accordingly decided to divide Africa into different regions and identify regional champions to coordinate activities therein, see Fig. 3, and a very preliminary steering committee (A.Roodt, convenor) was assembled.
The preliminary steering committee of AfCA was unfortunately not very active for some months, and discussions were continued at the follow-up conference in Rabat, Morocco, to reflect on events of the International Year of Crystallography (IUCr, 2015), with the Executive Committee of the European Crystallographic Association (ECA) taking the lead (Bacchi et al., 2017(Bacchi et al., -2019; ECA/IUCr, 2019); A. Roodt (ECA President, 2012-2015) and A. Bacchi (ECA President (2015-2018).
During this period, the efforts of C. Lecomte and M. Zema continued with the IUCr-UNESCO OpenLab initiative and other actions across Africa (Zema & Lecomte, 2014-2023, 2014, 2015;Zema et al., 2017), and should be recognized for significant contributions towards the expansion of crystallography and outreach in Africa.C. Lecomte as IUCr Executive Committee member and Vice President started with the first lectures in Dschang, Cameroon in 2013 (Bruker powder and single-crystal diffractometers also installed).This brought about the founding of the Cameroon Crystallographic Association, which was admitted as a member of the IUCr in 2014.Similarly, Morocco and Algeria were also admitted as members of the IUCr in 2014 (Haynes, 2023;IUCr, 2014a).Tunisia was admitted as a member of the IUCr in 2017 (IUCr, 2017).
In 2018, the X-TechLab (2016, 2018), a crystallography hub for Western Africa, was established in Benin by the IUPAP-IUCr LAAAMP initiative founded by S. Mtingwa, M. Zema and S. Scandolo in 2016 (Zema et al., 2016).Several training sessions, under the framework of the IUCr-UNESCO OpenLab initiative have since been organized there.
Illustrated in the accompanying photo (Fig. 4) are researchers from X-TechLab, Se `me `City, Benin, celebrating a milestone, i.e., the first example of a molecule synthesized in Sub-Saharan/Central Africa for which the structure was also solved in Sub-Saharan/Central Africa.
A more successful effort to formalize AfCA was then launched at the 1st Pan-African Conference on Crystallography in Dschang, Cameroon (IUCr, 2016), as well as at the IUCr-UNESCO Bruker OpenLab in Cote d'Ivoire (IUCr, 2018).Preliminary writing of the AfCA constitution and statutes commenced during this period (Bacchi et al., 2017(Bacchi et al., -2019)), with the thrust gaining significant momentum and resulting in the AfCA Steering Committee being formally constituted at the 2nd Pan-African Conference on Crystallography in Accra, Ghana (PCCr2/AfLS2, 2019), see Fig. 5.

Period 2020-2023
During this next period, interaction within the African community to streamline and activate more colleagues continued.This was achieved despite Covid-19 by the online Pan-African Conference on Crystallography during November 2021 (ePCCR, 2021), which was well attended, and future activities regarding AfCA were further refined.AfCA was formally constituted at ePCCR.The 17 current AfCA members, which are also the founder members, are: Algeria, Benin, Cameroon, Congo, Co ˆte d'Ivoire, Democratic Republic of Congo, Egypt, Gabon, Ghana, Kenya, Nigeria, Morocco, Rwanda, Senegal, South Africa, Tunisia and Zimbabwe (Haynes, 2023).The formation of AfCA was also ratified at the 33rd European Crystallographic Meeting in Versailles, France.(ECM33, 2022).
Final activities and all procedural matters were attended to at the second council meeting of AfCA at the 3rd Pan-African Conference on Crystallography in 2023 in Nairobi, Kenya (PCCr3, 2023).The formal constitution of AfCA, with D. Haynes as the first President, as the official fifth Regional Associate of the IUCr took place at the 26th Congress and General Assembly of the International Union of Crystallography in Melbourne, Australia, 22-29 August 2023(IUCr, 2023).

Future prospects
Challenges for AfCA once formally inaugurated certainly lie ahead, amongst others to expand African science significantly.Using crystallography as a multi-disciplinary vehicle, decisive and targeted actions are required, taking into account the ever-growing population of the continent (more than 50 countries, population over 1.3 billion), compared to Europe (44 countries, over 740 million inhabitants).Moreover, a concerted effort is necessary to pro-actively involve even more work from the material science, geology, mineralogy, physics, electron microscopy, African Lightsource and biology/protein communities.
It is, however, also incredibly important that the IUCr as custodian and the ECA continue to pro-actively interact with AfCA, and that the science ministries in all African countries become significantly more involved to enable AfCA to contribute not only to challenges directly associated with Africa, but also to the world, on issues such as pandemics and global warming.
It is impossible to acknowledge everyone who has contributed to an effort such as this, and to finally observe the birth of AfCA.Nevertheless, the tireless efforts and support from the IUCr, ECA and UNESCO, funding agencies across the globe, the private sector and government funding are gratefully acknowledged.Positive inputs from the reviewers of the original manuscript and the editor to the final paper are also gratefully acknowledged.However, in particular, all scientists involved for more than a century, and specifically all students appreciating the wonder of crystallography, are thanked and encouraged to do even better science and become even more involved.Crystallography is an ideal vehicle for this.

Table 1
Selected important time periods and events en route to the formation of AfCA; references are given in the main text.