Figure 1
Domain structure and amino-acid sequence of FYCO1. (a) Schematic representation of the domain structure of human FYCO1. The RUN (RPIP8, UNC-14 and NESCA) domain, coiled-coil region, FYVE (Fab1, YOTB/ZK632.12, Vac1 and EEA1) domain, LIR (LC3-interacting region) motif and GOLD (Golgi dynamics) domain are shown in green, blue, orange, purple and yellow, respectively. (b) Sequence alignment of FYCO1 RUN domains from mammals. The secondary-structural elements are indicated above the alignments. Nonconserved residues are highlighted in blue. |