issue contents

ISSN: 2053-230X

October 2023 issue

Highlighted illustration

Cover illustration: An inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1 [Moorefield et al. (2023), Acta Cryst. F79, 257–266]. Inorganic pyrophosphate (PPi) is generated as an intermediate or byproduct of many fundamental metabolic pathways, including DNA/RNA synthesis. The crystal structure of a family I inorganic pyrophosphatase from Legionella pneumophila, a human opportunistic pathogen that is the major causative agent of Legionnaires' disease, has been determined.

research communications

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Crystallization strategies for and structural analyses of all of the players in the faRel2/aTfaRel2 toxin–antitoxin system are reported.

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The crystal structure of a soluble family I inorganic pyrophosphatase from L. pneumophila Philadelphia 1 was determined to a resolution of 2.0 Å. Inorganic pyrophosphatases play a central role in regulating cellular pyrophosphate concentration, which is important for many biosynthetic pathways. L. pneumophila Philadelphia 1 causes a rare but severe respiratory infection known as Legionnaires' disease.

methods communications

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Guidance is provided on depositing raw diffraction data to support the results described in a macromolecular crystallography paper.

scientific commentaries

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The article by Moorefield et al. [(2023), Acta Cryst. F79, 257–266] demonstrates how structural genomics depositions can be used in undergraduate teaching.
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