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organic compounds
In the title compound, C14H18N4O3.2C12H14N4O2S.H2O, trimethoprim [5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4diamine, TMP] interacts with one sulfadimidine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, SDMD] molecule through two N-H
N hydrogen bonds forming an eight-membered ring, as in the 1:1 methanolate complex, with no proton transfer from the imino sulfonamide N atom to the pyrimidine N atom of the partner. Association with the second sulfadimidine molecule (SDMD') occurs through an N-HN interaction involving the same pyrimidine N atom of TMP (which therefore acts as a double acceptor) and the NH imino group of the sulfonamide. The water molecule bridges the sulfonamido O atom and the p-aminophenyl group of SDMD' of two molecular complex units.
N hydrogen bonds forming an eight-membered ring, as in the 1:1 methanolate complex, with no proton transfer from the imino sulfonamide N atom to the pyrimidine N atom of the partner. Association with the second sulfadimidine molecule (SDMD') occurs through an N-HN interaction involving the same pyrimidine N atom of TMP (which therefore acts as a double acceptor) and the NH imino group of the sulfonamide. The water molecule bridges the sulfonamido O atom and the p-aminophenyl group of SDMD' of two molecular complex units.
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