Isostructural Metabolites of Two Anti-Parkinson Drugs

The absolute configurations of desmethylselegiline hydrochloride [(R)-(-)-1-benzyl-N-(2-propynyl)ethylammonium chloride, C₁₂H₁₆N⁺.Cl^-], (1), and p-fluorodesmethylselegiline hydrochloride [(R)-(-)-1-(4-fluorobenzyl)-N-(2-propynyl)ethylammonium chloride, C₁₂H₁₅FN⁺.Cl^-], (2), have been determined. The two compounds are metabolites of the anti-Parkinson agent selegiline and its backup, p-fluoroselegiline. The two crystal structures are highly isostructural.

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