Surface representation of the endophilin SH3 domain. The surface representation is colour-coded by element, with red representing oxygen, blue nitrogen and gray carbon. The ligand-binding groove runs approximately vertically in this view. The base of the groove can be seen as the gray (hydrophobic) stripe flanked by red `walls' on either side. The side chain of Trp343 forms a ridge across the base of the groove.

View of a ribbon trace showing the rat endophilin A2 SH3 domain structure. The color scheme runs from blue at the N-terminus (residue 305 in the endophilin sequence) to red at the C-terminus (residue 368) of the domain. The RT loop is coloured cyan and the Src loop yellow-green. The ligand-binding groove lies between these two loops.