 | Acta Crystallographica Section A Acta Crystallographica Section A FOUNDATIONS AND ADVANCES |
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![[Figure 3]](sc5014fig3mag.jpg)
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Figure 3
(a) The Mpro dimer with bound peptidomimetic ester inhibitor N3. Mpro monomers are shown in ribbon representation and coloured red and blue. The peptidomimetic ester inhibitors (one per monomer) are shown in stick representation and coloured green. (b) The nsp7–nsp8 super-complex. The nsp7–nsp8 complex is shown in ribbon representation. Nsp7 is coloured green, one conformation of nsp8 is coloured blue and a second conformation of nsp8 is coloured orange. (c) The S protein fusion core. Shown from left to right are 1WYY (Duquerroy et al., 2005  ), 2BEZ (Supekar et al., 2004) and 1WNC (Xu et al., 2004). The central HR1 peptides are shown in ribbon representation and coloured red, blue and green. The HR2 peptides are shown in black. The N- and C-termini are labelled. (d) The S protein RBD bound to the cellular receptor ACE2. The complex structure is shown in ribbon representation with the ACE2 receptor coloured green, the S protein receptor binding domain (RBD) coloured blue and the S protein receptor binding motif (RBM) coloured red. (e) The S protein RBD bound to the 80R antibody. The complex structure is shown in ribbon representation with the 80R antibody coloured magenta, the S protein RBD coloured blue and the S protein RBM coloured red. The orientation of the S protein RBD is the same as for (d). (f) S2m, a rigorously conserved RNA element in the SARS-CoV genome. S2m is shown in stick representation and coloured according to the following scheme: GNRA-like pentaloop, is yellow; A-form RNA helices are blue and magenta; three-purine asymmetric bulge is red; seven-nucleotide bubble is green. |
![[Figure 3]](sc5014fig3.jpg)
| FOUNDATIONS ADVANCES |
ISSN: 2053-2733
