Figure 3
Side-chain detail from the human aldose reductase structure (Howard et al., 2004; PDB code 1us0
) for data truncated to 1.7 Å showing 50% probability ellipsoids after refinement with (a) no restraints, (b) standard SHELXL DELU and SIMU restraints, (c) TLS and additional isotropic B values using REFMAC, and (d) the new RIGU restraints. |