Figure 2
The electron-density map of (I) (Swiss-PdbViewer; Guex & Peitsch, 1997), showing the disordered state of (I) and the water molecules. Contours show the boundaries of 1.0 and 2.5σ. Three water molecules (O61, O62 and O63) bind when the phenyl ring swings into an alternate conformation designated by the primed atoms. |