Figure 3
The hydrogen-bonding assembly mode in (II), showing the fexofenadine dimer solvated by molecules of water (shown as small spheres), and further hydrogen bonding of this dimer to neighbouring molecules through atoms O2 and O3 [only the major disordered site (O2A) is shown; see also Table 4]. The dimer consists of molecules related by inversion at (). H atoms have been omitted for clarity, except for those attached to N and O atoms that are involved in the hydrogen bonding. Hydrogen bonds are denoted by dashed lines. The spheres marked with an asterisk (without H atoms attached to them) mark the O2A sites of two additional molecules of fexofenadine hydrogen bonded to the carboxylate groups of the central dimer. |