Figure 3
A superposition of the molecular conformations of triptans. The overlay was made by making a least-squares fit through the indole ring of eletriptan, (I). The labels and r.m.s. deviations (Å) are as follows: naratriptan, (II), 0.022; zolmitriptan (labelled 3), 0.028; sumatriptan (labelled 4), 0.017; almotriptan (labelled 5), 0.19; rizatriptan benzoate (labelled 6), 0.013; sumatriptan succinate (labelled 7), 0.017; almotriptan malate (labelled 8), 0.023. |