Figure 3
A superposition of the molecular conformations of the lenalidomide molecules of (I) and (II) with thalidomide. The overlay was made by making a least-squares fit through the isoindolinone ring system of (I). The labels and r.m.s deviations (Å) are as follows: molecule A of (II) [labelled (IIA)] 0.019; molecule B of (II) [labelled (IIB)] 0.020; thalidomide α form (labelled 3) 0.028; thalidomide β form 2 (labelled 4) 0.035. |