Figure 4
A superposition of the molecular conformations of erlotinib molecules. The overlay was made by making a least-squares fit through the quinazoline ring system of erlotinib–EGFR kinase complex (V). The labels and r.m.s. deviations (Å) are as follows: erlotinib hydrate, (I), 0.076; erlotinib hemioxalate, (II), 0.087; erlotinib hemifumaric acid dihydrate, (III), 0.07; erlotinib HCl, (IV), 0.076. |