Figure 2
(a) The unit-cell and molecular packing of Ala–Ala (Fletterick et al., 1970), with the inclusion of symbols for crystallographic symmetry operations. Voids at the fourfold axis, calculated in Mercury (Macrae et al., 2008) using a 1.2 Å probe with 0.5 Å grid spacing, account for approximately 5.8% of the unit-cell volume. (b) Part of the same structure, viewed along the a axis. (c) The crystal packing of Abu–Ala (Görbitz, 2002). The different sizes of the hydrophobic columns generated by the Abu and Ala side chains have been highlighted. (d) The crystal packing of (I); the colour coding is as in Fig. 1. Hydrogen bonds between Ser side chains (only component 1 is shown) are highlighted in the circle. In all parts, dashed lines indicate hydrogen bonds. |