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Figure 1
The synthesis of macozinone beginning from 2-chloro-3-nitro-5-(tri­fluoro­meth­yl)benzoic acid (1), which was directly converted to the benzamide derivative (2). Condensation of 2 with sodium 4-(cyclo­hexyl­meth­yl)piperazine-1-carbodi­thio­ate (3) afforded macozinone. The synthesis of macozinone reported by Makarov et al. (2014BB12) is highlighted in blue.

Journal logoSTRUCTURAL
CHEMISTRY
ISSN: 2053-2296
Volume 75| Part 8| August 2019| Pages 1031-1035
https://doi.org/10.1107/S2053229619009185
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