 | Acta Crystallographica Section D Acta Crystallographica Section D BIOLOGICAL CRYSTALLOGRAPHY |
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![[Figure 7]](be5044fig7mag.jpg)
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Figure 7
A model for tetraubiquitin (Ub4) binding to four Dsk2 UBA molecules. (a) The Dsk2 UBA molecules, arranged in a ninefold helix as in the UBA/UBL crystal structure, are labelled A, B, C and D and coloured red, magenta, blue and green, respectively. The Ub4 subunits, modelled on the UBL structure in the UBA–UBL complex, are labelled Q, R, S, T and colored yellow, orange, brown and yellow, respectively. They are linked by an isopeptide bond from the C-terminal G76 of one Ub molecule to K48 (shown in cyan) of the neighboring Ub molecule. (b) An enlarged view of the Dsk2 UBA dimer associated with the modelled Ub2 showing the C-terminal G76–K48 linker. (c) The HR23A UBA–Ub2 complex from Varadan et al. (2005  ) with the distal Ub molecule oriented as in the Ub molecule Q in (b). The diagram illustrates the different modes of association of the different UBA domains and the flexibility of the G76–K48 linker. |
![[Figure 7]](be5044fig7.jpg)
| BIOLOGICAL CRYSTALLOGRAPHY |
ISSN: 1399-0047
