Structural comparison of differently glycosylated forms of acid-β-glucosidase, the defective enzyme in Gaucher disease

Brumshtein, B.; Wormald, M.R.; Silman, I.; Futerman, A.H.; Sussman, J.L.

doi:10.1107/S0907444906038303

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 6
Putative membrane binding sites in crystal structures of GlcCerase. Catalytic residues are shown in red and loops 1–3 in green. Substrate binding was modelled according to Dvir et al. (2003

) and shown in yellow. (a) Some of the sulfates are shown in space-filling representation in red. (b) Side-on view [rotated ∼90° around the horizontal axis relative to (a)] of a putative mode of binding of GlcCerase to negatively charged phospholipids.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 62| Part 12| December 2006| Pages 1458-1465

https://doi.org/10.1107/S0907444906038303

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